This Water Resource Inventory and Assessment (WRIA) for Cache River National Wildlife Refuge summarizes available and relevant information for refuge water resources, including aquatic resource needs and issues of concern, both immediate and long-term. A primary purpose of the document is to provide recommendations to address any perceived water resource related threats, needs, or concerns on the refuge. Topics addressed within the WRIA report include the refuge’s natural setting (topography, climate, geology, soils, hydrology), effects of development within the associated watershed(s), potential effects from climate change, assessment and evaluation of refuge infrastructure in relation to water resources, historic and current water monitoring activities on and near the refuge, water quality and quantity information, and state water use regulatory guidelines.